1.
Bioorg Med Chem Lett
; 16(23): 5973-7, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16997556
RESUMO
This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent analogs disclosed showed low nanomolar activity for the inhibition of Lck kinase and a representative analog was co-crystallized with Hck (a structurally related member of the Src family kinases).